Andreas Fuchs - Postdoctoral Fellowship 2024
Project summary:
Coronary atherosclerosis in the Copenhagen General Population Study
In healthy persons, we will examine the relation between the early subclinical phase of coronary atherosclerosis detected by cardiac CT scans, clinical risk factors and later cardiac disease. We hypothesize that the degree of coronary atherosclerosis detected is a good predictor of the later cardiac prognosis.
Project Title
Coronary atherosclerosis in the Copenhagen General Population Study
Background
Cardiac disease originating from coronary atherosclerosis is a major cause of morbidity and mortality in the world, but it is hard to predict when a person is at risk for developing a myocardial infarction.
Aim
We aim to create a detailed description of the early subclinical phase of coronary atherosclerosis and the risk associated with this in order to be able to take preventive measures in selected persons.
Methods
Cardiac CT scans of >10.000 asymptomatic persons. Examined with respect to presence, obstruction, type, and quantitative measures of atherosclerosis. Follow-up time is >6 years.
Preliminary results
The first work showed that obstructive coronary atherosclerosis is associated with an 8-fold increased risk of myocardial infarction compared with no coronary atherosclerosis.
Andreas Fuchs
- MD and PhD
- Copenhagen University Hospital, Rigshospitalet
Mentors:
Ass. prof Klaus Fuglsang Kofoed, MD, PhD, DMSc, Dept Cardiol, Rigshospitalet
Tobias Kühl, MD, PhD, DMSc, Dept Cardiol, Roskilde Hospital
Collabortation:
Prof Lars Valeur Køber, MD, DMSc, Dept Cardiol, Rigshospitalet
Prof Børge Grønne Nordestgaard, MD, DMSc, Dept Clin Biochem, Herlev & Gentofte Hospital