Associate professor Thomas Jepps has arranged this one hour seminar with Professor Martin Young from University of Alabama.

• Join this seminar either in person or online. The presentation will be approx. 45 minutes long and afterwards there will be time for questions and discussions.
• Enjoy pastries and coffee at the meeting.
• Sign up to Tom Jepps tjepps@sund.ku.dk

Insights will be provided by Professor Martin Young regarding how the cardiomyocyte circadian clock regulates cardiac processes that are essential for normal contractile function, and the mechanisms by which circadian disruption leads to cardiac disease.

Dr Martin Young is a Professor of Medicine and Vice-Director for Research in the Division of Cardiovascular Disease at University of Alabama.

Both cardiac physiology (e.g., heart rate and contractility) and pathology (e.g., arrhythmia risk) fluctuate dramatically over the course of the day.  Recent studies suggest that these diurnal variations are secondary to daily fluctuations in factors that are extrinsic (e.g., neurohumoral stimulation) and/or intrinsic to the heart.  An intrinsic timekeeping mechanism, known as the circadian clock, has been characterized within cardiomyocytes, which temporally orchestrates fundamental cellular processes, ranging from transcription and translation, to signalling, electrophysiology, and metabolism.  Consistent with the transcriptional nature of the circadian clock, this mechanism regulates expression of a large proportion of the cardiomyocyte transcriptome, including both mRNA and miRNA species.