Professor Gilberto de Nucci will at this event critically discuss his experimental evidence for using a novel form of adrenergic regulation of the cardiovascular system. He has performed several experiments in this field.

He will be present some evidence on the inotropic effect of 6-ND*(see definition below) and its interactions with the classical catecholamines on isolated atria and the Langendorff heart preparation. In addition, he will identify novel endogenous catecholamines and their action in the circulatory system, and some data on possible biosynthetic pathways.

ABOUT:

Professor Gilberto de Nucci’s research focuses on the pharmacology of inflammation and cardiovascular disease. He is a professor of the Department of Pharmacology, School of Medical Sciences at the State University of Campinas & Professor of the Department of Biomedical Sciences Institute of Pharmacology at the University of São Paulo, Brazil.

*6ND: 6-nitrodopamine (6-ND) is a novel catecholamine that is released from vascular tissues such as human umbilical arteries and vein¹, Chelonoidis carbonarius aortic rings², Panterophis guttatus aortic rings³ and from rat isolated atria⁴ and from rat⁵ and human⁶ vas deferens (5,6). In the vascular tissues, 6-ND is a potent relaxant agent, acting as a truly selective dopamine D_2like-receptor antagonist^1,3. In the atria, 6-ND is 100x more potent than noradrenaline and adrenaline and 10,000x more potent than dopamine as positive chronotropic agent⁴.

• 1- Britto-Jr et al., 2021. Life Sci. 1;276:119425. doi: 10.1016/j.lfs.2021.119425.
• 2- Campos et al., 2021. Chromatogr B Analyt. 22;1173:122668. doi: 10.1016/j.jchromb.2021.122668.
• 3 - Lima et al., 2022. Comp Biochem Physiol C. 262:109471. doi: 10.1016/j.cbpc.2022.109471
• 4 - Britto-Jr et al., 2022. Life Sci. 15;307:120879. doi: 10.1016/j.lfs.2022.120879.
• 5 - Britto-Jr et al., 2021 Eur J Pharmacol. 15;911:174544. doi: 10.1016/j.ejphar.2021.17454
• 6 - Britto-Jr et al., 2022. Andrology. 10(8):1540-1547. doi: 10.1111/andr.13263