Anton Friis Mariager - PhD Scholarship 2023
Project summary:
The Ductus Arteriosus in Healthy Term Born Children. A Longitudinal study embedded in the Copenhagen Baby Heart Population Study
Through the Copenhagen baby heart project 25.000 newborns were from 2016 to 2018 examined with echocardiography. Based on this major population-based cohort study we aim to investigate the natural history of one of the most common congenital heart defects, the persisting ductus arteriosus.
Project Title
Targeting the kynurenine pathway of tryptophan degradation to combat abdominal aortic aneurysm
Background
The ductus arteriosus is an essential part of the prenatal circulatory system vital for the normal development of the fetus. After birth, it closes to prohibit shunting between the two major vessels departing the heart. However, the exact time of closure has shown to vary and in some the vessel do not close at all leading to a patent ductus arteriosus (PDA).
Aim
Trough 4 studies we aim to elucidate the natural history of the physiological early open ductus arteriosus and the patent ductus arteriosus while evaluating associated factors. Our findings can lead to a more qualified detection and may optimize treatment options.
Methods
All publications will be based on the prospective population-based cohort study, the Copenhagen Baby Heart Project. The research will follow an observational approach, investigating collected data and partaking in a follow-up cohort study.
Preliminary results
In a study we published this spring we documented the normal closure time of ductus arteriosus in healthy term born neonates. Additionally, we observed a stable population where the ductus does not seem to undergo spontaneous closure. In a forthcoming study we will present our findings on maternal, birth and neonatal factors as prognostic indicators for having a ductus arteriosus with delayed closure.
Anton Friis Mariager
- MD and PhD
- The Pediatric Department at Hvidovre Hospital, University of Copenhagen and The Cardiological Department at Herlev Hospital
Main supervisor:
Dorthe Lisbeth Jeppesen, MD, Clinical Associate Professor, PhD, Department of pediatrics Hvidovre Hospital.
Co-supervisors:
Mikkel Malham, MD, PhD, Department of pediatrics Hvidovre Hospital
Kasper Iversen, MD, prof, Department of internal medicin Herlev Hospital
Henning Bundgaard, MD, Prof, The Capital Region’s Unit of Inherited Cardiac Diseases, Rigshospitalet
Raheel Altaf Raja, MD, PhD, Department of Pediatrics and Adolescents Rigshospitalet, Copenhagen, Denmark
Collaborator:
The Copenhagen Baby Heart Study