Christian Velling Thorup - Cross-academy PhD Scholarship 2023
Project summary:
Polyamine treatment in elderly patients with coronary artery disease – a randomized controlled trial
The hypothesis is that a one-year daily dietary spermidine supplement has beneficial effects on heart and skeletal muscle, whole body composition, metabolism and gut microbiota in patients with coronary artery disease (CAD).
Project Title
Polyamine treatment in elderly patients with coronary artery disease – a randomized controlled trial
Background
The polyamine spermidine is found in all forms of life and are essential for cell growth and proliferation and induces cytoprotective autophagy in skeletal muscle. It is found in all plant-derived food and a high concentration of whole-blood spermidine is associated with longevity and individuals with a high dietary intake of spermidine have improved cardiovascular health and less obesity.
Aim
The aim in my PhD project is to examine the effects of spermidine in patients with CAD on whole body compositions, hormones, skeletal muscle and adipose tissue.
Methods
We plan to perform a randomized, double-blinded, placebo-controlled trial of 220 patients with CAD to investigate the effects of a daily oral spermidine dietary supplement vs. matching placebo in elderly patients with CAD.
Christian Velling Thorup
- MD
- Aarhus University
Main supervisors:
Henrik Wiggers, Professor, MD, PhD, DMSc, Department of Cardiology, Aarhus University Hospital
Niels Jessen, professor, MD, PhD, DMSc, Steno Diabetes Center, Aarhus University Hospital and Department of Biomedicine, Aarhus University
Collaborators:
Andreas Bugge Tinggaard, MD, PhD student, Department of Cardiology, Aarhus University Hospital
Chris Nørgaard Agerbo Jeppesen, MD, PhD student, Department of Cardiology, Aarhus University Hospital
Won Yong Kim, professor, MD, PhD, DMSc, Department of Cardiology, Aarhus University Hospital
Contact:
- Christian.thorup@rm.dk