Jakob Solgaard Jensen - PhD Scholarship 2023
Project summary:
Cardiovascular function and Metabolic profile in Adolescents born after Assisted Reproductive Technologies – CARMAART study
Young adults born after frozen embryo transfer have raised arterial blood pressure and metabolic disorders compared to individuals conceived after fresh embryo transfer and naturally.
A clinical cohort study of young adults conceived after frozen (n=100) and fresh (n=100) embryo transfer compared to young adults conceived naturally (n=100).
Objective 1: To investigate the 24-hours systemic arterial blood pressure. Primary outcome: Mean systolic and diastolic blood pressure over 24 hours.
Objective 2: To investigate blood pressure and cardiac function at rest and dynamic exercise. Secondary outcome: Diastolic function at rest and exercise.
Objective 3: To investigate biochemical and anthropometric metabolic parameters. Secondary outcome: Insulin sensitivity (HOMA-IR).
Project Title
Cardiovascular function and Metabolic profile in Adolescents born after Assisted Reproductive Technologies – CARMAART study
Background
Assisted reproductive technologies (ART) account for up to 6.5% of annual births in industrialized countries and over 10 million births world-wide. Considering the increasing use of ART and the limited studies of possible repercussions in the offspring, it is paramount to establish the safety of ART.
Aim
To investigate cardiovascular and metabolic alterations in young individuals born after ART signifying the need for prophylactic measures to prevent future cardiovascular disease in generations of children and young adults born after ART.
Preliminary results
11 months from initiation we have examined 122 participants (41%) and included 166 (55%).
Jakob Solgaard Jensen
- MD
- Fertility Department, Copenhagen University Hospital, Rigshospitalet
- University of Copenhagen
Main suoervisor:
Anja Bisgaard Pinbor, MD, DMSc, Professor, Department of Cardiology, Copenhagen University Hospital - Herlev Hospital
Co-supervisor:
Per Lav Madsen, MD, DMSc, Department of Cardiology, Copenhagen University Hospital - Herlev Hospital
Lasse Glieman, MSc, Ph.D ass.professor, The August Krogh Section for Human Physiology, University of Copenhagen
Rikke Beck Jensen, MD, Ph.d. DMSc, Department of Pediatrics, Copenhagen University Hospital - Herlev
Gorm Greisen, MD, DMSc, professor, Department of Neonatology, University hospital – Rigshospitalet
Collaborators:
Iben Bache, Ass. professor, Clinical Genetics Clinic, Copenhagen university hospital, Rigshospitalet
Eva R. Hoffmann, professor, Department of cellular and molecular medicine, Faculty of Health and Medical Sciences, University of Copenhagen
Niels Vejlstrup, PhD, MD, Department of Cardiology, Rigshospitalet
Tine Clausen, PhD, MD, Gynaekologisk Obstetrisk Afdeling, Nordsjællands University Hospital Hillerød