Manan Pareek - Postdoctoral Fellowship 2022

Project summary:
Does bedtime administration of cardiovascular drugs improve clinical outcomes?

A significant number of patients with cardiovascular disease experience (recurrent) events. Moreover, most cardiovascular disease events occur during the morning hours. Administration of select cardiovascular drugs at bedtime may mitigate this risk. The study will provide us with unique knowledge regarding the optimal timing for antihypertensive, aspirin, and rivaroxaban administration.

Project Title

Randomized comparisons of morning versus bedtime drug administration: The cardiovascular circadian chronotherapy (C3) trial program

Background

Cardiovascular disease is the second most common cause of death in Denmark. High blood pressure is the most prevalent risk factor for cardiovascular disease and constitutes a major burden on healthcare systems. However, only a third of affected individuals achieve target blood pressures. Most manifest cardiovascular conditions are atherosclerotic in nature and thus predispose to vascular stenosis and thrombosis. An additional common cardiovascular disorder with a strong relation to hypertension is atrial fibrillation, a condition that further perpetuates the risk of stroke and systemic embolism. Several medications used for treatment of these conditions may have additional benefits when administered with dinner or at bedtime rather than early in the morning.

Aim

To examine whether administration of antihypertensive drugs, aspirin, and rivaroxaban at bedtime versus in the morning provides a superior reduction in incident major adverse cardiovascular events.

Methods

A series of open label, randomized, controlled trials. Patients who fulfill relevant inclusion and exclusion criteria will be identified through the National Patient and Prescription Registries, contacted, and asked to participate. Once they sign an informed consent form, study participants will be randomized to receive their once-daily antihypertensive medications, aspirin, and rivaroxaban (as relevant) in the morning versus at bedtime. Outcome data will be collected through the National Patient Registry.

Manan Pareek

  • MD and PhD
  • University of Copenhagen, Center for Translational Cardiology and Pragmatic Randomized Trials, Department of Biomedical Sciences, Faculty of Health and Medical Sciences

Mentors:

Tor Biering-Sørensen, Center for Translational Cardiology and Pragmatic Randomized Trials, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen

Michael Hecht Olsen, Section of Cardiology, Department of Internal Medicine, Holbæk Hospital

Collaborators:

  • Deepak L. Bhatt, Brigham and Women’s Hospital Heart & Vascular Center, Harvard Medical School, Boston, USA
  • Muthiah Vaduganathan, Brigham and Women’s Hospital Heart & Vascular Center, Harvard Medical School, Boston, USA

Contact: